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EC number: 265-084-5
CAS number: 64741-82-8
A complex combination of hydrocarbons from the distillation of the products from a thermal cracking process. It consists predominantly of unsaturated hydrocarbons having carbon numbers predominantly in the range of C10 through C22 and boiling in the range of approximately 160°C to 370°C (320°F to 698°F).
Cracked gas oil was found to be irritating to the skin after 4 hour, semi-occlusive exposure. The mean erythema score was 2.7 (24,48,72 hours), while the mean oedema score was 1.33 (24,48,72 hours).
Cracked gas oils are not considered irritating to the rabbit eye.
gas oils are found to be irritating to the skin, but not irritating to
the key dermal irritation study, three male New Zealand White rabbits
were exposed to 0.5 mL of light catalytic cracked distillate under
semi-occlusive conditions for 4 hours (Exxon1996). Animals were observed
for 10 days following exposure, during which no clinical signs were
observed. Well-defined erythema was observed in one animal, and moderate
to severe erythema was observed in two animals at the 1, 24, 48, and 72
hour observation time points. Moderate to slight oedema was observed in
all animals. The mean erythema score was 2.7 (24, 48, and 72 hours),
while the mean oedema score was 1.33 (24, 48, and 72 hours). Erythema
and oedema resolved by day 10, and therefore the study was terminated at
supporting studies, rabbits
were dermally exposed to cracked gas oil under semi-occlusive conditions
for 24 hours. In ARCO
1992f, the mean erythema score was 2.19 (24, 72 hours), while the mean
oedema score was 2.29 (24, 72 hours). In
ARCO 1989f, 1989g, and 1989h, individual animal data were not provided,
so mean erythema and oedema scores useful for classification cannot be
provided data do indicate irritation to rabbit skin after dermal
Based on results of
available studies, cracked gas oils are classified as irritating to
In the key study
identified for eye irritation (API 1985a), light catalytically cracked
distillate was tested for eye irritation potential in a group of nine
male New Zealand White rabbits. No pain response, corneal or iridial
irritation was observed. Blanching conjunctivae was exhibited by one
animal with unwashed eyes at the 1-hour time point. Irritation resolved
by 72 hours, and no systemic toxicity was observed throughout the study
period. The mean irritation scores were 0/80 for corneal, 0/10 for
iridial, and 0.44/20 for conjunctival irritation, for both washed and
additional eye irritation supporting studies ( ARCO 1991a, 1989i, 1989j,
1989k), rabbits were exposed to cracked gas oil and observed for
irritation noted was mild and fully reversible.
Based on these
results, cracked gas oils are not classified as irritating to the rabbit
support that cracked gas oils are skin irritants (API, 1985a; API,
1985b;). Additional data support that cracked gas oils are not eye
irritants (API, 1985b;). This information is presented in the dossier.
Justification for selection of skin irritation / corrosion endpoint:
one of 7 acute irritation studies producing similar results
Justification for selection of eye irritation endpoint:
One of 6 acute occular irritation studies showing similar results.
Effects on skin irritation/corrosion: irritating
Based on a mean
erythema score of 2.7 (24, 48, 72 hours), and a mean oedema score of
1.33 (24, 48, 72 hours), cracked gas oils are classified as Skin
Irritant Cat.2, H 315, irritating to the skin according to EU
CLP Regulation (EC No. 1272/2008)
Based on a lack of
corneal and iridial irritation, and a conjunctival irritation score of
0.44/20, cracked gas oils are not classified as irritating to eyes
according to EU
CLP Regulation (EC No. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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