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EC number: 265-084-5
CAS number: 64741-82-8
A complex combination of hydrocarbons from the distillation of the products from a thermal cracking process. It consists predominantly of unsaturated hydrocarbons having carbon numbers predominantly in the range of C10 through C22 and boiling in the range of approximately 160°C to 370°C (320°F to 698°F).
The acute oral toxicity of light
catalytically cracked distillate was evaluated in fasted male and female
Sprague Dawley rats. The test substance was administered undiluted at
dose levels of 2050, 3200, 5000, or 6250 mg/kg in females and 3200,
5000, or 6250 mg/kg in males. The animals were observed hourly for
clinical signs and mortality for 6 hours after test material
administration, then twice daily thereafter for 14 days. Body weights
were recorded prior to, and at 7 and 14 days after, test material
administration. All animals were sacrificed 14 days post-treatment and
subjected to a gross necropsy.
Clinical signs included hypoactivity;
diarrhoea; yellow or brown-stained anal, genital and abdominal areas;
hair loss on abdomen; ataxia; red-stained nose and mouth; prostration;
lacrimation; hypothermic to touch; and death. Mortality was
observed in 1 of 5, 3 of 5, and 4 of 5 males at dose levels of
3200, 5000, and 6250 mg/kg, respectively. In females, mortality was
observed in 0 of 5, 3 of 5, 4 of 5, and 5 of 5 animals at dose levels of
2050, 3200, 5000, and 6250 mg/kg, respectively. No abnormal
necropsy findings were reported. An oral LD50 of 4660 mg/kg body weight
(males, 95% C.I.: 3.5-6.18) and 3200 mg/kg body weight (females, 95%
C.I.: 2.31-4.43) was reported by the study authors. The test material is
not classified according to EU criteria.
This study received a Klimisch score of 2
and is classified as reliable with restrictions because it is an
acceptable and well documented study report.
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