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EC number: 265-084-5
CAS number: 64741-82-8
A complex combination of hydrocarbons from the distillation of the products from a thermal cracking process. It consists predominantly of unsaturated hydrocarbons having carbon numbers predominantly in the range of C10 through C22 and boiling in the range of approximately 160°C to 370°C (320°F to 698°F).
Table 1. Mean body weight data expressed
as a percentage of day 0 weight.
In an acute inhalation
toxicity study, groups of young adult COBS (CD) BR rats were exposed by
inhalation route to light catalytically cracked distillate aerosol for 4
hours via whole-body exposure at measured concentrations of 0, 2.34,
3.47, 5.06, 6.34, or 7.29 mg/L. Animals then were observed for 14 days.
There were no deaths
during the exposure period in any of the investigations, and macroscopic
and microscopic findings were limited to the lungs, where moderate to
severe pulmonary irritation was apparent. Clinical signs commonly
included dyspnea and discharge from the nose and eyes. Decreased
activity and mobility was reported at concentrations of 3.47 mg/L or
6.34 mg/L but not in male rats at 7.29 mg/L or either sex at 5.06 mg/L.
During the observation period, mortality was observed in 0 of 5, 1 of 5,
0 of 5, 3 of 5, 3 of 5, and 5 of 5 male rats at measured exposures of 0,
2.34, 3.47, 5.06, 6.34, and 7.29 mg/L, respectively. In females,
mortality was observed in 0 of 5, 0 of 5, 1 of 5, 1 of 5, 5 of 5, and 5
of 5 animals at the measured exposures of 0, 2.34, 3.47, 5.06, 6.34, and
7.29 mg/L, respectively. The inhalation LC50 was determined to be 4.65
mg/L (95% C.I.: 3.89 to 5.55 mg/L) in males and females, and 4.65 mg/L
(95% C.I.: 4.22 to 5.13 mg/L) in males. The test material is classified
as harmful by inhalation according to EU criteria.
This study received a
Klimisch score of 1 and is classified as reliable without restriction
because it closely followed OECD guideline 403.
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