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EC number: 265-084-5
CAS number: 64741-82-8
A complex combination of hydrocarbons from the distillation of the products from a thermal cracking process. It consists predominantly of unsaturated hydrocarbons having carbon numbers predominantly in the range of C10 through C22 and boiling in the range of approximately 160°C to 370°C (320°F to 698°F).
In a dermal sensitisation study (Beuhler
method), undiluted light catalytically cracked distillate was dermally
applied to the clipped backs of 10 male Hartley albino guinea pigs
during the induction phase, and a subsequent challenge dose was applied
at a 10% v/v dilution of test substance in paraffin oil. Approximately
0.4 mL of test
material was applied under occlusion for a 6 -hour exposure to one
clipped area on each animal, once per week for 3 weeks during induction
(total of three applications). The same test site was used for each
application. Two weeks following the administration of the final
induction application, a challenge dose (0.4 mL) was administered to the
test groups on a different site and reactions recorded at 24 and 48
One control animal was found dead on day 16. Following
the challenge application, very slight erythema was present in three of
the nine surviving animals. These reactions did not exceed the highest
reaction of the naïve control animals. The other test animals exhibited
no reaction following challenge treatment. The
naïve control group also exhibited very slight erythema in three of the
control animals, indicating a lack of a sensitising response in the
treated animals. Based
on these results, light catalytically cracked distillate was not a skin
sensitiser when tested using a closed patch technique in guinea pigs.
study received a Klimisch score of 2 and is classified as reliable with
restrictions because it is an acceptable and well documented study report.
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