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EC number: 203-227-5
CAS number: 104-68-7
Irritation scores calculated
The acute eye irritation/corrosion study in New Zealand White rabbits
was conducted to evaluate the eye irritation potential of Diethylene
glycol mono phenyl ether. One-tenth of a milliliter (0.1 ml) of the
undiluted test item was instilled into the conjunctival sac of the left
eye of the animal after gently pulling the lower lid away from the
eyeball. The eyelids were held together gently for about one second to
minimize loss of test item. The right eye remained untreated and served
as the reference control. All the rabbits were treated in a similar
manner. The ocular lesions were evaluated at 1, 24, 48, 72 hours, 4, 7,
10, 14, 17 and 21 days post instillation according to the scale for
scoring ocular lesions. In addition, the treated eyes were examined
using ophthalmic fluorescein sodium at 24, 72 hours, at 7 and 14 days
post instillation. The total mean scores were 18, 27.34, 27.34, 27.34,
25.34, 22.06, 34.67, 27.33, 27.33 and 18.67 at 1, 24, 48, 72 hours, 4,
7, 10, 14, 17 and 21 days, respectively. Mild circumcorneal injection
was observed in one rabbit from day 10 onwards and in the other two
rabbits from day 14 onwards till termination of observation (day 21).
There were no toxic signs and pre-terminal deaths.
Based on the evidence of irritation and the persistence of effects until
the end of the observation period, the test material meets the criteria
for Category 1 A according to CLP.
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