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EC number: 203-227-5
CAS number: 104-68-7
The acute dermal toxicity of Diethylene glycol mono phenyl ether was
tested in male and female Wistar rats.
Based on the individual body weight, the undiluted test item at the dose
of 5000 mg/kg body weight (a volume of 4.5 ml/kg bodyweight) was applied
directly to the prepared skin of the animal, taking care to spread the
substance evenly over the entire dose area, and covered with a cotton
gauze (size: 9 x 5 cm of 6 ply for males and 8 x 5 cm of 6 ply for
females) and secured in position by adhesive tape wound around torso.
The test item contact period with the skin was for 24 hours. After 24
hour contact period with the skin, the unabsorbed test item at the site
of application was removed by wiping with water and the rats were
observed for 15 days. There were no toxic signs, local skin reactions
and pre-terminal deaths. There were no abnormalities detected at
Based on the above results it is concluded that the LD50 of Diethylene
glycol mono phenyl ether is greater than 5000 mg/kg bodyweight.
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