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EC number: 203-227-5
CAS number: 104-68-7
No data is available for DiEPH. However Two repeated dose (104 weeks)
OECD 451 and GLP compliant studies in rats and mice, respectively, are
available for similar material 2 -phenoxyethanol. The available data
indicate that 2-phenoxyethanol is not carcinogenic.
Based on the assessment of all available
data classification in accordance with EU Directive 67/548/EEC
(DSD) and EU Classification, Labeling and Packaging of Substances and
Mixtures (CLP) Regulation No. 1272/2008 is not warranted
Two carcinogenicity (104 weeks) OECD
451 and GLP compliant studies are available. A drinking water study was
conducted with F344/DuCrlCrlj rats. 50 rats per sex were exposed to
nominal concentration of 0, 2500, 5000, and 10000 mg/L. Analytical
concentrations in drinking water were determined with HPLC. Based on
chemical intake data the mean intake of test substance across the
duration of the study was estimated to be 124, 249, and 510 mg/kg/day in
males and 191, 380, and 795 mg/kg/day in females. Mortality and clinical
signs were investigated. Food intake, water intake and body weight were
determined weekly during the first 13 weeks followed by measurements
once every 4 weeks until study termination. After 104 weeks urinalysis,
haematology, blood chemistry, gross pathology, organ weights and
histopathology (both non-neoplastic and neoplastic lesions) were
examined. No neoplastic lesions were found in either sex. Additionally,
a drinking water study with B6D2F1/Crlj mice was conducted. The study
design and examination/observations were similar to the study in rats.
However, the dose levels differed and were 0, 5000, 10000 and 20000
mg/L. Based on chemical intake data the mean intake of test substance
across the duration of the study was estimated to be 468, 898, and 1701
mg/kg/day for males and 586, 1072, and 2058 mg/kg/day for females. After
104 weeks repeated dosing, no treatment related neoplastic lesions were
found in either sex. Based on both rat and mice studies, there is no
evidence of carcinogenic activity of the test substance in male or
female rat and mice.
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