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EC number: 227-873-2
CAS number: 6018-92-4
Experimental observations and irritation
scores are given in table 1 and table 2, respectively.
The negative control showed no irritating
effects on the blood vessels. The calculated mean irriation score was
Solutions of SDS (1%) and NaOH (0.1 N) were
used as positive controls. The positive controls induced a severe
irritation on the blood vessels. The calculated mean irriation score
were 10.48 for SDS and 19.56 for NaOH.
The test item Nickel Hydrogencitrat showed
effects on the blood vessels of the CAM. The calculated mean irriation
score was 5.85.
Under the experimental conditions, the test
item is moderately irritating to the eyes.
Table 1: experimental
Positive Control 0.1 NaOH
Positive Control 1% SDS
Calculation of the irritation score
The irritation score was calculated
from the following equation:
IS= ((301 -time until haemorrhage)/300)*5 +
((301 -time until lysis)/300)*7 + ((301 -time until coagulation)/300)*9
The calculated IS for each replicate
and the corresponding means are presented in the following table:
Table 2: irritation score
Mean Irritation Score
Classification of the irritation
potential is made as stated in the table 3:
Irritation Score (IS)
0 - 0.9
1 - 4.9
5 - 8.9
9 - 21
The validity criteria and findings are
given in the table 4:
IS of negative controls
IS of positive controls
19.56 (NaOH)10.48 (SDS)
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