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EC number: 227-873-2
CAS number: 6018-92-4
In the performed in vitro tests, the test substance nickel hydrogencitrate did neither have skin irritation nor eye irritation potential.
Two in vitro test were performed in
order to assess the irritation potential of nickel hydrogencitrate:
The skin irritation potential of nickel
hydrogencitrate was tested according to the draft OECD guideline "In
vitro skin irritation: human skin model test", dated December 2007. The
administration of 25 mg of the test substance to the human skin model
EpiDermTMdid not cause effects, e. g. loss of viability,
suggesting irritation potential.
The in vitro HET-CAM test following the
ICCVAM test method (dated November 2006) was performed to evaluate the
irritation potential of nickel hydrogencitrate. The application of 300
µL of the test substance on the chorioallantoic membrane (CAM) of
incubated chicken eggs did not cause effects related to irritation, e.
g. haemorrhage, lysis or coagulation, on the CAM.
Based on the results of the in vitro studies,
it is predicted that the test substance nickel hydrogencitrate is not
irritating to the skin and the eye in vivo.
Nickel hydrogencitrate and Trinickel
dicitrate are comparable: Since citric acid is a multifunctional acid,
at different pH values various intermediate ions like citrate,
hydrogencitrate and dihydrogencitrate are formed.
There is conclusive data available which is
not sufficient for classification.
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