Registration Dossier
Registration Dossier
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EC number: 217-157-8 | CAS number: 1758-73-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (28 d) ≥ 100 mg/L for activated sludge microorganisms (OECD 301C)
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
Two studies are available investigating the effects of
aminoiminomethanesulphinic acid (CAS No. 1758-73-2) to
microorganisms.The key study investigated the effects on microorganisms
in a biodegradation study according to OECD 301C under GLP conditions
(Ministry of Economy, Trade and Industry, Japan, 1991). The study was
performed with a mixture of activated sludge from STP with freshwater
from rivers and lakes, marine water and marine sediment. No inhibition
of biodegradation was observed after 28 d. The test concentration from a
biodegradation study which indicated that the test substance is readily
biodegradable can be used to derive a NOEC for this endpoint as stated
in the ECHA Guidance R.7b (ECHA, 2012). Therefore, the test item
concentration of 100 mg/L can be used as NOEC value for the toxicity to
activated sludge microorganisms. Thus a NOEC (28 d) of ≥ 100 mg/L
resulted.
An additional study confirmed the low toxicity
ofaminoiminomethanesulphinic acid to microorganisms (Coenen, 1988). The
inhibition of cell multiplication was investigated in a study according
to NEN 6509. Twelve concentrations up to 1000 mg/L (nominal) were
tested. After incubation of 18 h a toxicity threshold value of 538 mg/L
was derived . The toxicity threshold is not an accepted endpoint for the
risk assessment but it indicated a low toxicity of the test substance to
microorganisms.
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