Registration Dossier
Registration Dossier
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EC number: 268-130-2 | CAS number: 68003-46-3
Endpoint summary
Administrative data
Description of key information
Additional information
Ammonium N-methyl-N-(1-oxododecyl)glycinate (CAS 68003-46-3) is a substance containing 290 g/L of the main constituent (Ammonium lauroyl sarcosinate) and 70% of water serving as additive. Furthermore, the substance is a salt characterized by low vapour pressure (5.10E-05 Pa, 25 °C, MPBVP v1.43), indicating that it is not volatile and that evaporation to air and subsequent transport through the atmosphere to other environmental compartments is not likely.
Since there is only limited experimental data available for the environmental fate of the substance, QSAR calculations were performed to estimate the dissociation constant (pKa), log Koc and log Kow values of the substance.
The calculated pKa of the substance is 3.3 ± 0.4 (QSAR, ACD I-Lab 2.0), indicating that the anionic form will predominate at environmentally relevant conditions of pH 4 to 9, which is expected to remain in solution. The estimated log Koc (ChemProp v6.5, Franco, Fu & Trapp) is 2.99 at pH 4 and 1.99 at pH 7 and 9, indicating a low potential for adsorption to particles present in soil and sediment in neutral to basic environments and a low to moderate potential for adsorption in more acidic environments. Thus, the substance is expected to be mobile in surface waters at environmentally relevant pH values of around 7.
Ammonium N-methyl-N-(1-oxododecyl)glycinate has a log D (used for ionisable substances instead of log Kow) of 3.28 at pH 4, 0.61 at pH 7 and -0.30 at pH 9 (SPARC v4.6) , indicating low lipophilicity at the environmentally relevant pH of 7 and 9. Thus, according to REACh regulation (EC) No 1907/2006 the substance has a low potential for bioaccumulation at the environmentally relevant pH of 7 and 9 as the log D is ≤ 3. Furthermore, the estimated BCF values also indicate that the potential for bioaccumulation is low. The estimated BCF values range from 3.16 to 150.7 L/kg wet-wt and are thus well below the threshold value of 2000 L/kg for bioaccumulative substances, as laid down by the REACH regulation (EC) No 1907/2006, section 1 of Annex XIII.
Based on experimental results from a standard biodegradation study, the substance is readily biodegradable (98.2% 28 d, OECD 301 A). Consequently, abiotic degradation via hydrolysis is not a relevant degradation pathway. According to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances can be expected to undergo rapid and ultimate degradation in most environments, including biological sewage treatment plants (STPs) (ECHA, 2016). Hence, release into the environment is expected to be low due to ready biodegradability. Moreover, the substance will not persist in surface waters and bioavailability to aquatic organisms can therefore be expected to be low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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