Registration Dossier
Registration Dossier
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EC number: 268-130-2 | CAS number: 68003-46-3
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 23 May 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Remarks:
- EPISuite v4.1 (KOWWIN v 1.68)
- Justification for type of information:
- The test item is a solution of 29 % ammonium lauroyl sarconsinate (component 1) and 1 % ammonium Iaurate (component 2) in water. As component 1 is surface active (surface tension of the mixture is 37.71 ± 0.19 mN/m at 20.0 °C, LAUS study No. 15121103G960) and the substance is not a pure substance, none of the experimental methods for determination of the log Pow is applicable. Therefore the log Pow for the two components is calculated using the program kowwin v1.68 (part of EPI suite 4.1, US EPA. 2011: Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.10. (United States Environmental Protection Agency, Washington, DC, USA). The non-ionized form (i.e. the free acids instead of the ammonium salts) are used for calculation.
- Principles of method if other than guideline:
- QSAR calculation
- GLP compliance:
- no
- Type of method:
- other: QSAR
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 4.1
- Remarks on result:
- other: Lauroyl Sarcosinate
- Remarks:
- (est.) KOWWIN v1.68
- Type:
- log Pow
- Partition coefficient:
- 5
- Remarks on result:
- other: Lauric acid
- Remarks:
- (est.) KOWWIN v 1.68
Reference
Results
The calculated Log Kow (using kowwin v 1.68) for Lauroyl sarcosinate is 4.10 and is 5.00 for Lauric acid.
Description of key information
Main constituent: Log Kow of Lauroyl sarcosinate is 4.10 (EPISuite v 4.10, KOWWIN v1.68).
Impurity: Log Kow of Lauric acid is 5.00 (EPISuite v 4.10, KOWWIN v1.68).
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
