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EC number: 203-812-5
CAS number: 110-88-3
Trioxane proofed not to be sensitizing in a guinea pig
maximization test (BASF AG, 1989). The study was performed
according to the OECD guideline 406 and GLP.
Additionally an epicutaneous test on 84 dentists, dental
technicians and specialist auxilliary staff with contact eczema was
performed (Berova et al., 1990). Trioxane was included as desinfectant
in dental applications. 31 patients were diagnosed with a work related
contact dermatitis, only one of them (1.2%) with an allergy against
Even though trioxane proofed not to be sensitizing in guinea pig
tests and from human experience, it is known that trioxane degradation
results in the release of small amounts of formaldehyde
(formaldehyde-releasing agent). Formaldehyde is a well known human skin
sensitizer and from this perspective possible implications for
formaldehyde-susceptible individuals should be indicated in the hazard
No data available:
No classification for sensitization indicated according to Directive
67/548/EEC and Directive 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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