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EC number: 203-812-5
CAS number: 110-88-3
Trioxane proofed not to be sensitizing in a guinea pig
maximization test (BASF AG, 1989). The study was performed
according to the OECD guideline 406 and GLP.
Additionally an epicutaneous test on 84 dentists, dental
technicians and specialist auxilliary staff with contact eczema was
performed (Berova et al., 1990). Trioxane was included as desinfectant
in dental applications. 31 patients were diagnosed with a work related
contact dermatitis, only one of them (1.2%) with an allergy against
Even though trioxane proofed not to be sensitizing in guinea pig
tests and from human experience, it is known that trioxane degradation
results in the release of small amounts of formaldehyde
(formaldehyde-releasing agent). Formaldehyde is a well known human skin
sensitizer and from this perspective possible implications for
formaldehyde-susceptible individuals should be indicated in the hazard
No data available:
No classification for sensitization indicated according to Directive
67/548/EEC and Directive 1272/2008.
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