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EC number: 203-812-5
CAS number: 110-88-3
No signs of skin irritation in a OECD 404 GLP study on rabbits. No signs of eye irritation in a OECD 405 GLP study with rabbits. Transient signs of local respiratory tract irritation following repeated dose inhalation applications.
In an OECD 404 GLP study the
semioccclusive application of trioxane to the skin of rabbits for 4h did
not result in signs indicative for skin irritation (Hoechst, 1989).
Erythema and edema scores were reported as 0, however no data
regarding individual Draize scores are available.
In a further incompletely
reported skin irritation study with rabbits, no apparent irritation was
reported following occlusive application of trioxane for 24h (IHFA,
1962). According to this study no classification for skin irritation is
indicated, although the only result reported is a primary irritation
score of 0.
Additionally data from a guinea
pig maximization test indicated no skin irritation within 96h following
2 x 24h occlusive applications of a 75% trioxane solution (BASF AG,
Based on the Hoechst-study
(1989) trioxane was not legally classified for skin irritation (reported
erythema and edema scores of 0) (C&L 2002).
In an OECD 405 GLP study trioxane was reported to be not
irritating to the eyes of rabbits (Hoechst, 1989). Instillation of
trioxane in the eyes for 24 h did only result in mild reversible
irritation of the conjunctivae and slight reversible chemosis (mean
values: conjunctivae 1.7, chemosis 0.7, cornea 0, iris 0.1, fully
reversible after 72 h).
In an incompletely reported eye irritation study with rabbits,
reversible signs of mild eye irritation were observed (mild iritis,
corneal opacity, conjunctivitits). According to the results of this
study no classification according to Directive 67/548/EEC would be
required but classification as a mild eye irritant (Cat.2B) according to
Additional data indicates only mild eye irritant properties of trioxane
in rabbit eyes (BASF AG, 1968). No classification would be required
according to this study. In this study a smaller amount of test
substance was instilled into the eyes of 2 animals only and no rinsing
Based on the Hoechst (1989) study trioxane was not legally
classified for eye irritation (C&L 2002).
Due to transient signs of local respiratory tract irritation observed in
repeated dose inhalation studies, trioxane was classified as a
respiratory tract irritant.
EU: R37, GHS: STOTsinglecategory 3 (H335, may cause
No classification for skin and eye irritation according to Directive
67/548/EEC and Directive 1272/2008.
Trioxane was classifid as a respiratory tract irritant. EU: R37, GHS:
STOTsingle category 3 (H335, may cause respiratory irritation).
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