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EC number: 203-812-5 | CAS number: 110-88-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with GLP, however no data pertaining to individual Draize score are available (Documentation insufficient for assessment)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Remarks:
- (Hoechst AG, Toxicology and Pathology)
Test material
- Reference substance name:
- 1,3,5-trioxane
- EC Number:
- 203-812-5
- EC Name:
- 1,3,5-trioxane
- Cas Number:
- 110-88-3
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 1,3,5-trioxane
- Details on test material:
- - Name of test material (as cited in study report): Trioxane
- Physical state: crystals
- Analytical purity: 99.1%
- Impurities (identity and concentrations): ca. 0.1% Triethanolamine, ca. 0.8% water
- Storage condition of test material: 4 °C in dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund
- Age at study initiation: ca. 3-5 months
- Weight at study initiation: 2.2-2.5 kg
- Diet (e.g. ad libitum): Altromin 2123 (ca. 15 g daily)
- Water (e.g. ad libitum): deionised water
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±3
- Humidity (%): 50±20
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- physiological saline
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg (0.2 ml of physiol. saline was used to make paste) - Duration of treatment / exposure:
- 4 h
- Observation period:
- 30-60 min, 24, 48, and 72 h after removal of test substance
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- dorsal area of trunk was clipped 24h before application of test substance
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes with luke warm water
- Time after start of exposure: 4 h
Results and discussion
Any other information on results incl. tables
No irritation responses were observed, however no data pertaining to individual Draize score are available.
Applicant's summary and conclusion
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