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EC number: 203-812-5
CAS number: 110-88-3
Acute toxicity studies on all three trophic levels are available. The
results indicate that 1,3,5-trioxane cause no acute toxicity on these
trophic levels. For the fresh water fish Leuciscus idus a LC50 (96h) of
4000 mg/L (nominal) and for salt water species (Cyprinodon variegatus)
a LC50 (96 h) of 16350 mg/L was reported. No toxicity to Daphnia magna
in the highest test concentration (1000 mg/L) was measured. Based on the
growth rate the EC50 (72 h) for algae (Scenedesmus subspicatus)
was determined to be >500 mg/L. No studies on chronic toxicity to fish
and aquatic invertebrates are available. However, in Annex IX of
Regulation (EC) No 1907/2006, it is laid down that long-term toxicity to
fish or aquatic invertebrates shall be proposed by the registrant if the
chemical safety assessment indicates the need to investigate further the
effects on aquatic organisms. According to Annex I of this regulation,
the chemical safety assessment triggers further action when the
substance or the preparation meets the criteria for classification as
dangerous according to Directive 67/548/EEC or Directive 1999/45/EC or
is assessed to be a PBT or vPvB. The hazard assessment of 1,3,5-trioxane
reveals neither a need to classify the substance as dangerous to the
environment, nor is it a PBT or vPvB substance, nor are there any
further indications that the substance may be hazardous to the
environment. Moreover, since trioxane shows an unspecific mode of action
a EpiWin v4.00 EcoSAR v1.00 calculation was conducted to estimate the
chronic toxicity to fish. The result of this calculation showed no
chronic toxicity to fish (ChV > 1000 mg/L). Therefore, long-term
toxicity tests neither in fish nor in aquatic invertebrates are provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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