Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-812-5 | CAS number: 110-88-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Original publication in Czech; only few data could be extracted from an English abstract and from tables; However, peer reviewed data used as supporting data for HPV submission (US EPA); Scientifically acceptable.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Experimental studies of toxic effects of 1,3,5-trioxane and 1,3-dioxolane. I. Acute toxic effects
- Author:
- Czajkowska T, Krysiak B and Popinska E
- Year:
- 1 987
- Bibliographic source:
- Med Pr Vol 38 :184-190
- Reference Type:
- secondary source
- Title:
- 1,3,5-TRIOXANE, CAS Number 110-88-3, USEPA HPV Challenge Program Submission
- Author:
- Trioxane Manufacturers Consortium Members, BASF Performance Copolymers, LLC (Formerly Ultraform Company) and Ticona
- Year:
- 2 000
- Bibliographic source:
- USEPA HPV Submission
Materials and methods
- Principles of method if other than guideline:
- The acute systemic toxicity of trioxane in rat following single administration by gavage was examined and the LD50 was determined using the Litchfield and Wilcoxon method.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1,3,5-trioxane
- EC Number:
- 203-812-5
- EC Name:
- 1,3,5-trioxane
- Cas Number:
- 110-88-3
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 1,3,5-trioxane
- Details on test material:
- Trioxane
Purity assumed to be ca. 98% (impurities reported: 2% H2O, 0.5% CH2O, 0.1% HCOOH)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Designation: Wistar rats
Source: no data
Age at test initiation: no data
Body weight range at test initiation: 250 - 300 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- Not recognizable
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Statistics:
- The determination of the LD50 was based on the Litchfield and Wilcoxon method.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 8 500 mg/kg bw
- 95% CL:
- 7 320 - 9 860
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
