2,6-dibromo-4-cyanophenyl heptanoate

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

activated sludge respiration inhibition testing

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Please refer to the analogue approach justification document provided in Section 13.

Reason / purpose for cross-reference:

read-across source

Key result

Duration:

3 h

Dose descriptor:

EC50

Effect conc.:

> 1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

inhibition of total respiration

Remarks on result:

other:

Remarks:

From the Key study M-171475-01-1

Description of key information

From the source activated sludge key study, the 3-hour EC₅₀ for microorganisms exposed to the present test material was > 1000 mg/L.

Key value for chemical safety assessment

EC50 for microorganisms:

1 000 mg/L

Additional information

Data on the toxicity to micororganisms are not available. In accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. , the assessment is based on the structurally analogue substance (CAS 1689-99-2).Please refer to the attached analogue justification for further details on the read-across approach.

 

The source key study (2000) is available for toxicity towards microorganisms. In this study, the effects of the substance towards microorganisms were investigated in a 3-h toxicity test with activated sludge under static conditions. The study was carried out according to GLP and OECD guideline 209. Activated sludge was exposed to nominal concentrations of 10, 32, 100, 320 and 1000 mg/L, alongside with a control. Based on nominal concentrations an EC₅₀ of > 1000 mg/L was determined.