Registration Dossier
Registration Dossier
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EC number: 260-300-4 | CAS number: 56634-95-8
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to analogue justification provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 35 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 4.9 µg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- length
- Remarks on result:
- other:
- Remarks:
- convert from Bromoxynil phenol to Bromoxynil octanoate. From Key source study M-160841-01-1.
- Duration:
- 35 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 3.4 µg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- other:
- Remarks:
- Bromoxinyl phenol
- Basis for effect:
- length
- Remarks on result:
- other:
- Remarks:
- From Key source study M-160841-01-1.
Reference
Description of key information
From the key source study, the overall NOEC for the early life stages of P. promelas is 0.0049 mg a.i./L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- NOEC
- Effect concentration:
- ca. 0.005 mg/L
Additional information
Data on the long-term toxicity of the substance to fish are not available. In accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. , the assessment is based on the structurally analogue substance (CAS 1689-99-2). Please refer to the attached analogue justification for further details on the read-across approach.
In the key source study the long-term effects of the substance towards fish were examined in early-life stage toxicity test with P. promelas under flow-through conditions (1991). The study was carried out according to GLP and US EPA-72.4 guidelines. Fish were exposed to mean measured concentrations of 0.0034, 0.0057, 0.0086, 0.018 and 0.039 mg a.i./L, alongside with a control and a solvent control. Based on mean measured concentrations of the test substance a NOEC 0.0049 mg a.i./L was determined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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