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EC number: 695-930-2
CAS number: 13676-53-4
LD50 (experimental) >2000 mg/kg bw (LD50
cut-off = 5000 mg/kg bw), study conducted according to OECD 423, GLP
In the present study conducted according to
OECD guideline 423 (adopted 17 December 2001), m-Xylylenebismaleimide
was tested in three steps and two doses for acute oral toxicity. In step
1, 300 mg/kg bw were adminstered and in steps 2 and 3, 2000mg/kg bw were
administered to three female rats each group and the animals were
observed for 14 days. There were no premature deaths in step 1, thus
step 2 was performed, one animal died in step 2 and all animals showed
clinical signs during the first 5 to 7 days which were reversible. Most
prominent clinical signs were reduced spontaneous activity, sunken
flunks, piloerection , half eyelid closure, prone position and between
observation day 3 and 4 diarrhoea and weight loss. Body weight loss
occurred in step 2 and 3 but all animals gained weight in a normal range
at the end of the study. between observation day 7 and 15 there were no
specific findings in step 2 and 3. The animal that died showed
discoloured, dark duiodenum, jejunum, ileum - with Peyer´s patches-
during necropsy. Necropsy was also performed with the remaining animals
at day 15 but showed no specific findings.
Oral LD50 (rat, females) >2000 mg/kg bw
(LD50 cut-off = 5000 mg/kg bw)
Based on the available, reliable and
relevant data m-Xylylenebismaleimide is not classified with regard to
acute oral toxicity according to Regulation (EC) No 1272/2008 (CLP);
according to GHS (Globally Harmonized Classification System)
m-Xylylenebismaleimide is classified into Category 5 and has obliatory
labelling requirements for toxicity.
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