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EC number: 695-930-2
CAS number: 13676-53-4
- QSAR prediction, The Estimation Programs
Interface (EPI) SuiteTM v4.1, BIOWIN estimation model (v4.10), not
- Supporting data from 2,4
-Bismaleimidotoluene, study according to OECD TG 301B, GLP, not readily
the present report biodegradability was estimated by QSAR prediction
using EPISuite and the Biowin models. m-Xylylenebismaleimide is
considered to be not readily biodegradable based on the QSAR prediction.
BIOWIN estimates the probability of rapid aerobic and anaerobic
biodegradation of an organic compound in the presence of mixed
populations of environmental microorganisms. BIOWIN contains seven
separate models. These models predict the biodegradability based on
structural features and molecular weight. The molecular weight as well
as the fragments which can be derived from the chemical structure are
used in the models training data set, thus the substance lies in the
applicability domain of the prediction models and the prediction is
a supporting study conducted according to OECD TG 301B, GLP, the
biodegradability of the structurally similar compound 2,4
-Bismaleimidotoluene was determined.
test medium was inoculated with activated sludge from a sewage treatment
plant mainly fed with municipal wastewater. The rate of degradation was
monitored by measuring the carbon dioxide produced over the 28-d period.
test item was tested with a concentration of 19 mg/L in duplicates. The
biodegradation of the test item was followed by titrimetric analyses of
the quantity of CO2 produced by the respiration of bacteria. The
degradation was finished on day 28 by acidification, the last titration
was made on day 29. The percentage CO2 production was calculated in
relation to the theoretical CO2 (ThCO2) of the test item. The
biodegradation was calculated for each titration time.
10 % level (beginning of biodegradation of the test item) was not
reached 14 days of the test. The pass level of 60 % was not reached at
the end of the study period. The mean biodegradation came to a maximum
of 17 % after 28 days.
check the activity of the test system sodium acetate was used as
functional control. The percentage of degradation of the functional
control reached the pass level of 60 % after 10 days.
the toxicity control containing both test and reference item a
biodegradation rate of 39 % occurred within 28 days .
test item m-Xylylenebismaleimide is not readily biodegradable in this
CO2 evolution test and failed the 10 d window criterion.
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