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EC number: 695-930-2
CAS number: 13676-53-4
- QSAR prediction, The Estimation Programs
Interface (EPI) SuiteTM v4.1, BIOWIN estimation model (v4.10), not
- Supporting data from 2,4
-Bismaleimidotoluene, study according to OECD TG 301B, GLP, not readily
was estimated by QSAR prediction using EPISuite and the Biowin models.
m-Xylylenebismaleimide is considered to be not readily biodegradable
based on the QSAR prediction. BIOWIN estimates the probability of rapid
aerobic and anaerobic biodegradation of an organic compound in the
presence of mixed populations of environmental microorganisms. BIOWIN
contains seven separate models. These models predict the
biodegradability based on structural features and molecular weight. The
molecular weight as well as the fragments which can be derived from the
chemical structure are used in the models training data set, thus the
substance lies in the applicability domain of the prediction models and
the prediction is considered reliable.
a supporting study conducted according to OECD TG 301B, GLP, the
biodegradability of the structurally similar compound 2,4
-Bismaleimidotoluene was determined.
test medium was inoculated with activated sludge from a sewage treatment
plant mainly fed with municipal wastewater. The rate of degradation was
monitored by measuring the carbon dioxide produced over the 28-d period.
test item was tested with a concentration of 19 mg/L in duplicates.
biodegradation of the test item was followed by titrimetric analyses of
the quantity of CO2 produced by the respiration of bacteria. The
degradation was finished on day 28 by acidification, the last titration
was made on day 29. The percentage CO2 production was calculated in
relation to the theoretical CO2 (ThCO2) of the test item. The
biodegradation was calculated for each titration time.
pass level of 60 % was not reached at the end of the study period. The
mean biodegradation came to a maximum of 17 % after 28 days.
check the activity of the test system sodium acetate was used as
functional control. The percentage of degradation of the functional
control reached the pass level of 60 % after 10 days.
the toxicity control containing both test and reference item a
biodegradation rate of 39 % occurred within 28 days .
test item m-Xylylenebismaleimide is not readily biodegradable in this
CO2 evolution test and failed the 10 d window criterion.
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