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EC number: 240-521-2
CAS number: 16470-24-9
NOEC (fry length, fry weight) = 4.41 mg/l
(TWA, mean measured)
The long-term toxicity to fish was
evaluated considering data on a similar substance. Justification for
Read Across is given in Section 13 of IULCID.
The effects of the similar substance 1
-MSA on the early-life stage of fish (Danio rerio/Zebrafish) were
determined according to OECD Guideline 210. Dimethylsulfoxide (DMSO) was
used as solvent with a concentration of 0.10 ml/l dilution water. Based
on the results of a range finding test the test was conducted as a
dose-response test with the nominal test item concentrations 0.301,
0.723, 1.74, 4.17 and 10.0 mg/l. The test was started by placing
fertilized eggs into the test vessels and it lasted 34 days (30 days
post-hatch). 80 eggs of Danio rerio / zebrafish were exposed to each
test concentration, the solvent control and the control (4 replicates
with 20 eggs each). The water quality parameters pH-value, oxygen
concentration, temperature and total hardness were within the acceptable
limits. On study day 4, 95% of the control and 98% the solvent control
larvae had hatched. Therefore, study day 4 was defined as post hatch day
0 (= PHD 0). Hatching success, fry growth (assessed via length and fresh
weight measurements on PHD 30), morphological and behavioral effects,
posthatch survival and overall survival were assessed. Specific analysis
of various concentrations of the test item in the test media and the
controls was carried out via HPLC-DAD. The measured concentrations of
replicates and test media on study days 0 to 34 (last sampling on study
day 28) were in the range of 87 to 124 % of the nominal concentrations.
Since the measured concentrations were partly out of the range of ± 20%
of the nominal concentration, the time-weighted arithmetic mean measured
concentrations of the test item were calculated, resulting in 0.339,
0.796, 1.72, 4.41 and 10.8 mg/l, respectively.
The test item partly caused significant
effects on Zebrafish in an early life stage test. For the parameters
hatch, post-hatch survival and overall survival the NOEC was 10.8 mg/L.
Therefore, the respective LOECs were determined to be > 10.8 mg/l. For
the parameter fry growth (expressed as length and fresh weight) the NOEC
was 4.41 mg/l. Therefore, the LOEC for this parameter was determined to
be 10.8 mg/l.
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