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EC number: 240-521-2
CAS number: 16470-24-9
Intact skin reactions
Abraded skin reactions
The skin irritation potential was tested
in New Zealand White rabbits. The procedure used is described in the
Proposed Guidelines of the United States Environmental Agency (EPA) §
163.81-5 "Primary dermal irritation study", Federal Register, Vol. 43,
No. 163, August 22, 1978.
Under the conditions of the present
experiment the test compound was found to cause a slight irritation when
applied to intact and abraded rabbit skin. The calculated primary
irritation index was 1.5. One animal died after 6 days.
The scoring system criteria used to record
the hardness of the skin reactions followed in the current test are the
same as those reported into the OECD guideline, therefore it is possible
to re-evaluate the results according to the CLP Regulation (EC
1272/2008), because the raw tables are included into the study report.
Only the intact skin reactions were considered.
Mean values from gradings at 24, 48 and 72
hours after patch removal were lower than 2.3 in all animals for both
erythema/eschar and oedema reactions (in both intact and abraded skin).
In conclusion, the test item can be
classified as NON irritating, according to the CLP (EC 1272/2008)
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