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EC number: 240-521-2
CAS number: 16470-24-9
Short term toxicity
Fish: LC50 (96 h) > 1000 mg/l
Aquatic invertebrates: EC50 (48h) > 100
Algae: ErC50 (72h) > 123 mg/l (nominal);
NOEC (72h, growth rate) = 30.8 mg/l (nominal)
Fish: NOEC (fry length, fry weight) = 4.41
mg/l (TWA, mean measured)
Aquatic invertebrates: NOEC
(21d, overall threshold effects) = 1.10 mg/l
The toxic potential of the
substance to aquatic algae was evaluated considering data on
the substance itself and on analogous substances. Justification
for Read Across is given in Section 13 of IUCLID. The
toxicity to fish and to aquatic invertebrates was entirely
based on data on the substance itself.
Acute toxicity for Zebra
fish was evaluated in the 96 hours screening test, according
to the OECD guideline 203. Two concentrations were
administrated at 562 and 1000 mg/l with no effect (Ciba -
Geigy Ltd., 1992).
The study result is
supported by other studies performed between 1973 and 1999
on Zebra fish at 96h for which only a summary is available
indicating LC50 all greater than 1000 mg/l. Furthermore, a
prolonged semistatic assay over 14 days was conducted with
Brachydanio rerio. Endpoints were mortality, signs of
intoxication, length and weight. The nominal concentrations
were 100, 316 and 1000 mg/l. There was no mortality and no
difference in body weight at nominal concentrations of 100
and 316 mg/l. Only at 316 mg/l one fish showed slackening in
movement (Bayer AG., 1992).
Acute toxicity to Daphnia
magna was evaluated in the 48 hours test, according to the
EU method C2. A single dose was administrated at 100 mg/l
(limit test). No dead occurred (Bayer AG., 2000). The result
was confirmed by two supporting studies, one performed at
just 24h (RCC Umweltchemie AG, 1988) and the other one at
48h, but just the summary is available (Solvias AG, 1999),
with no effect up to 1000 mg/l.
The toxicity of the
substance to aquatic algae was evaluated by considering data
on similar substances obtained in studies conducted
according to the OECD Guideline 201 and under GLP
conditions. Supporting data from studies on the substance
itself is also taken into consideration. The following
results were obtained for the similar substances:
(72h) > 123 mg/l (nominal); NOEC (72h, growth rate) = 30.8
3a-DSA: ErC50 (72hrs) > 110
mg/l (nominal); NOEC (72hrs, growth rate) = 110 mg/l
The influence of 3a-MSA
on the growth of the green alga Scenedesmus subspicatus
chodat was also investigated. The study was performed
according to the OECD Guideline 201. Based on the growth
inhibition curve, the NOEC and the LOEC values were found to
be 500 mg/l and 1000 mg/l, respectively. The EC50 values
after 72 and 96 hours was >1000 mg/l (RCC Umweltchemie AG.,
1990). The result is in agreement with a second study on the
substance, for which just a summary is available (Solvias
Following a conservative
approach, the effect levels obtained in the study on
3a-A(Na) (lower NOEC) are considered for the chemical safety
assessment considering the toxicity to aquatic algae.
Regarding long-term studies, a fish
early-life stage toxicity study on the similar substance 1 -MSA was
considered, performed according to OECD Guideline 210. Based on the
results of a range finding test the test was conducted as a
dose-response test with the nominal test item concentrations 0.301,
0.723, 1.74, 4.17 and 10.0 mg/l corresponding to 0.339, 0.796, 1.72,
4.41 and 10.8 mg/l (base on time-weighted arithmetic mean measured
concentrations. For the parameters hatch, post-hatch survival and
overall survival the NOEC was 10.8 mg/l. Therefore, the respective
LOECs were determined to be > 10.8 mg/l. For the parameter fry
growth (expressed as length and fresh weight) the NOEC was 4.41
mg/l. Therefore, the LOEC for this parameter was determined to be
Daphnia magna reproductive study
is available on the substance conduected accorting to the OECD
Guideline 211 in which the NOEC was determined as 6.59 mg/l.
The following results were obtained
for the similar substances, obtained in studies conducted according
to the OECD Guideline 211 and under GLP conditions:
3a-A(Na): NOEC (21d,
overall threshold effects) = 3.22 mg/l; NOEC (21d,
reproduction) = 3.22 mg/l
3a-DSA: NOEC (21d, overall
threshold effects) = 2.0 mg/l; NOEC (21d, reproduction) =
1 -MSA: NOEC (21d, overall
threshold effects) = 1.10 mg/l; NOEC (21d, reproduction) =
Following a conservative
approach, the results obtained in the long-term toxicity study
on acquatic invertebrates on the Similar Substance 1 -MSA will
be used for the chemical safety assessment.
Considering the available
data on the three trophic levels, daphnia is considered to be
the most sensitive species as the effect level during the
long-term reproductive study was the lowest obtained.
Therefore, SELECTED NOEC for
aquatic toxicity: 1.10 mg/l from the 21-days reproductive
Daphnia study on the analogue substance 1 -MSA.
The study conducted on the similar
substance 1 -MSA is used for the chemical safety assessment,
following a conservative approach. More information on the
results of the substances of the category are found on the
document attached under "Ecotoxicological information".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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