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EC number: 240-521-2
CAS number: 16470-24-9
The effects of the test article on the
integrity and performance of male and female reproductive systems,
including gonadal function, estrous cycle, mating behaviour, conception,
gestation, parturition, lactation, weaning and growth and development of
the spring were assessed testing rats, according to the EPA OPPTS
870.3800 (Reproduction and Fertility Effects) guideline.
Animals were exposed to the test article
daily, via oral gavage at the dose levels of 0, 100, 300 and 1000 mg/kg
bw, at a constant volume of 10 ml/kg. The duration of the entiere study
was approx. 9 months.
Based on the results, the No Observed
Adverse Effect Level (NOAEL) for parental toxicity was 300 mg/kg/day and
for parental reproductive performance, the NOAEL was 1000 mg/kg/day. For
offspring growth and development, the NOAEL was also 1000 mg/kg/day.
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