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EC number: 240-521-2
CAS number: 16470-24-9
The active ingredient
used in these experiments
was at the beginning,
during and at
the completion of the half of
the experiment was tested for acute
toxicity. This always
resulted in a same normal
Groups of 6 male and 6 female rats
were given during 10 weeks (5 doses/week) 30, 60, 120, 250 or 500 mg
of the test substance/kg as a solution in oil administered by
gavage. A further group of 12 male and 12 female rats received daily
5.0 ml of oil/kg (control). During the experimental period, the
condition of the animals was observed daily, body weights (all
animals) were weekly recorded; blood and Harnstatus (3 males and 3
females per dose) were analysed at 14 -days, and at the end of the
test, the prothrombin time (3 males and 3 female sper group) and in
all animals the SGPT and SGOT Transaminases and SDH were determined
24 hours after the last
administration, the animals were sacrificed with ether and the
internal organs (liver, kidneys, adrenals, thyroid, spleen, ovary,
testis, lung) macroscopically examined and weighed.
No adverse effetcts were recorded: the
animals of the experimental groups showed no apparent symptoms of
poisoning and behaved similarly to the control animals.
The bodyweight is not significantly
altered in the experimental groups compared with the control groups.
The complete blood count, the checks of liver function tests and the
urine tests did revealed no pathological findings.
After killing the rats, the internal
organs in the experimental groups compared with the control groups
did not appear changed and a significant dose-dependent change in
the absolute and relative organ weights could not be determined (P >
0.1) in the experimental groups compared with the control group.
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