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EC number: 700-960-7
CAS number: 68512-30-1
numerical skin grades at
1, 4, 24, 48 and 72 hours
scores at 7 to 21 days
In a primary skin irritation/corrosion study in the rabbit
(4-hour semi-occlusive application), oligomerisation and alkylation
reaction products of 2-phenylpropene and phenol (phenol,
methylstyrenated) was applied (0.5 ml via surgical gauze) to a 2 x 3
cm patch on three shaved New Zealand White rabbits. One hour after 4
hours exposure, well defined or moderate to severe erythema (grades
2-3) and slight oedema (grade 2) were observed in the treated skin
areas of the three animals. An increase in the degree of erythema and
oedema were observed at the following observations, with a maximum of
moderate oedema (grade 3) after 24 hours and of moderate to severe
erythema (grades 3-4) 72 hours after exposure. Fissuring of the
treated skin was also observed in one animal (no. 1964) after 72
hours. A decrease in the degree of skin irritation was noted from 7
days onwards, and the irritation had completely resolved within 21
days after exposure in all animals.Scalinesswas observed on the
treated skin in all animals after 7 days and persisted in two animals
at 14 days after exposure. There was no evidence of a corrosive
effects on the skin, nor were there any observed signs of systemic
toxicity during the test period. In conclusion, application of phenol,
methyl styrenated to intact rabbit skin results in severe irritation,
and as such phenol, methylstyrenated should be classified as a skin
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