Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

No specific toxicokinetic data are available, either for the entire substance Oligomerisation and alkylation reaction products of 2-phenylpropene and phenol [EC no. 700-960-7] or for single key constituents of the substance.

Key value for chemical safety assessment

Additional information

No quantitative information can be provided. However, the low molecular masses (about 230 - 360) are principally bioavailable via the gastro-intestinal route to some extent. They are likely to be metabolised or conjugated to variable degree in the liver to more water-soluble species that can be excreted into the urine or released into the bile and faeces changed or unchanged, but also be able to enter the circulatory system with the unchanged portion able to distribute to adipose tissue. Similar to related arylaromatic structures, they are unlikely to accumulate, at least at low exposure levels.

Penetration into and through the skin can be anticipated, too, due to the small molecular size and lipophilicity; however, this is likely to happen distinctly less than after oral ingestion due to the barrier function of the cutis.