Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-960-7
CAS number: 68512-30-1
INDIVIDUAL OCULAR CHANGES
Time after dosing
Animal 1935 (#1)
Animal 1941 (#2)
Animal 1975 (#3)
(.) = Score given for: A = Eyelids
= Nictitating membrane
DRAIZE SCORE CALCULATIONS
Hours after application
Three male rabbits had 0.1 ml phenol, methylstyrenated instilled in
their eyes for 24 hours. Following this period, the test substance was
washed out, using 2 % fluorescein in water to reveal any signs of
irritation. The instillation resulted in minimal irritation of the
conjunctivae, irritation of chemosis in two animals and redness in all
three animals. In one animal a small amount of dicharge was observed 1
hour after instillation. These symptoms were resolved 48 hours after
instillation, and no corneal epithelial damage was seen in any of the
animals 24 hours after the instillation. There was no evidence of ocular
corrosion nor was there any peri-ocular staining of tissues by the test
substance. No toxic symptoms were observed in the animals during the
test period, and no mortality occurred. In conclusion, instillation of
the test substance into rabbit eyes induced minimal irritation, which
was reversible within 48 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again