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EC number: 700-960-7
CAS number: 68512-30-1
INDIVIDUAL OCULAR CHANGES
Time after dosing
Animal 1935 (#1)
Animal 1941 (#2)
Animal 1975 (#3)
(.) = Score given for: A = Eyelids
= Nictitating membrane
DRAIZE SCORE CALCULATIONS
Hours after application
Three male rabbits had 0.1 ml phenol, methylstyrenated instilled in
their eyes for 24 hours. Following this period, the test substance was
washed out, using 2 % fluorescein in water to reveal any signs of
irritation. The instillation resulted in minimal irritation of the
conjunctivae, irritation of chemosis in two animals and redness in all
three animals. In one animal a small amount of dicharge was observed 1
hour after instillation. These symptoms were resolved 48 hours after
instillation, and no corneal epithelial damage was seen in any of the
animals 24 hours after the instillation. There was no evidence of ocular
corrosion nor was there any peri-ocular staining of tissues by the test
substance. No toxic symptoms were observed in the animals during the
test period, and no mortality occurred. In conclusion, instillation of
the test substance into rabbit eyes induced minimal irritation, which
was reversible within 48 hours.
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