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EC number: 700-960-7
CAS number: 68512-30-1
The substance oligomerisation and alkylation reaction products of
2-phenylpropene and phenol (OAPP) (previous name phenol,
methylstyrenated) shows low oral, inhalation, and dermal acute toxicity.
Discriminating doses (oral studies) were determined to be 2000 mg/kg bw
(no mortality observed). Application of the substance as aerosol at a
concentration of 4.92 mg/L did not result in any mortality (LC50 > 5000
mg/m³). The LD50 obtained in an acute dermal toxicity study was > 2000
mg/kg bw. Combined results indicate that OAPP is of low acute toxicity
independent of the application route.
The particle size analysis of the atmosphere drawn from the animals’
breathing zone, was as follows
[see Report Appendices 1 and 2]:
Concentration +-SD [mg/L]
(n = 17)
Mean Mass Median
[µm] (n = 3)
[wt% <4 µm]
Table No. 1: Individual body
weight of animals – 2000 mg/kg – males
Body weight gain (g)
Table No. 2: Individual body
weight of animals – 2000 mg/kg – females
The test substance applied on skin at a
dose of 2000 mg/kg of animal weight did not cause death of animals.
signs of intoxication (piloerection, decreased response to stimuli, red
secretion around eyes) were
observed in all males and four females. Irritation on the skin was
observed after application of the test substance in one female. Symptoms
of irritation faded away on 12thday after application of the
test substance. Decreased body weight in females was recorded in period day
0-8 of the study.
Macroscopic changes were diagnosed during pathological examination in
one female (liver – light colour).
Four GLP compliant studies have been conducted on the acute oral
toxicity endpoint using the substance oligomerisation and alkylation
reaction products of 2-phenylpropene and phenol (previous name phenol,
methylstyrenated) (specifically; three OECD 423 and one OECD 401). In
one study, 2 animals died following treatment (though no specific cause
of death was noted). No other deaths occurred in the three other
studies. The discriminating doses/LD50 recorded for each study are 2000
and greater than 2000 mg/kg bw, respectively. The overwhelming weight of
evidence would suggest that OAPP is not likely to be acutely toxic via
the oral route.
Two GLP compliant studies (OECD 402) have been conducted on the
acute dermal toxicity endpoint using the substance oligomerisation and
alkylation reaction products of 2-phenylpropene and phenol. No deaths
were recorded in either study. As such it can be concluded that OAPP has
a low acute dermal toxic potential. The LD50 in both studies was greater
than 2000 mg/kg bw, and no significant treatment related toxicities were
A GLP compliant study was conducted on the substance
oligomerisation and alkylation reaction products of 2-phenylpropene and
phenol (as an aerosol) via the inhalation route. No animal deaths were
noted during the study. The maximum dose given was 4.92 mg/L per animal
+/- 0.46 mg/L. The LD50 was estimated to be greater than 4.92 mg/L. For
classification purposes, it has been assumed that the LD50 is greater
than 5.00 mg/L. This is because there was no mortality and the margins
of error quoted for the study exceed the threshold for
For all three application routes, data from acute toxicity limit tests
with concentrations set to the upper limit for classification are
available. Mortality in all tests was absent or low. For oral
application, the discriminating dose in three studies was 2000 mg/kg bw.
For inhalation and dermal route, distinct LD(C)50 values could not be
determined (LD(C)50 > limit concentration). Based on these results,
classification according to Regulation (EC) 1272/2008 (CLP Regulation)
is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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