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EC number: 216-653-1 | CAS number: 1634-04-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- SUB-C-2114439301-60-01/F
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent substance: Samples taken immediately, and then after 2.4, 24 and 120 hours.
- Sampling method: At each sampling time, two samples were removed from the oven and an aliquot (2 mL) of each was diluted to volume (20 mL) with acetone. The samples were filtered (0.45 μm, PTFE) before analysis by gas chromatography (GC).
- Sampling methods for the volatile compounds, if any: Not applicable
- Sampling intervals/times for pH measurements: pH and temperature measured at the start and end of test.
- Sampling intervals/times for sterility check: Not required as only preliminary phase conducted and no evidence of hydrolysis was observed.
- Sample storage conditions before analysis: Samples analysed immediately.
- Other observation, if any (e.g.: precipitation, color change etc.): None specified. - Buffers:
- pH 4: 0.2M aqueous potassium dihydrogen orthophosphate (110 mL) was mixed with 0.07M aqueous disodium hydrogen orthophosphate dodecahydrate (250 mL) and purified water (640 mL). The pH was adjusted to 4.0 ± 0.05 with orthophosphoric acid.
pH 7: 0.2M aqueous potassium dihydrogen orthophosphate (500 mL) was mixed with 1M sodium hydroxide (60 mL) and purified water (1440 mL). The pH was measured as 7.0 ± 0.05.
pH 9: 0.1M boric acid in 0.1M aqueous potassium chloride (1000 mL) was mixed with 1M sodium hydroxide (42 mL) and purified water (958 mL). The pH was adjusted to 9.0 ± 0.05 with 1M sodium hydroxide. - Estimation method (if used):
- Not applicable
- Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: Glass wheaton vials (10 mL)
- Sterilisation method: Standard cleaning practices
- Lighting: Samples incubated in darkness
- Measures taken to avoid photolytic effects: Samples incubated in darkness
- Measures to exclude oxygen: Buffer solutions purged with Nitrogen before use.
- If no traps were used, is the test system closed/open: Test system closed with crimp-seals. Stock solutions and samples taken through the septum to minimise volatilisation.
- Is there any indication of the test material adsorbing to the walls of the test apparatus? None noted.
TEST MEDIUM
- Volume used/treatment: 1 mL of a stock solution (8 g/L) of the substance in water.
- Kind and purity of water: Purified water.
- Preparation of test medium: Not applicable
- Renewal of test solution: Not applicable
- Identity and concentration of co-solvent: No co-solvent used.
OTHER TEST CONDITIONS
- Adjustment of pH: The pH of the buffer solutions were adjusted before use as required. No pH adjusment was required after test solutions added.
- Dissolved oxygen: Not specified - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 738.1 - <= 763.6 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 832 - <= 842.8 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 759.9 - <= 804.9 mg/L
- Number of replicates:
- Sampled in duplicate
- Positive controls:
- no
- Negative controls:
- no
- Statistical methods:
- Not a guideline requirement
- Preliminary study:
- The preliminary study showed that at each of pH 4, 7 and 9 and 50 ± 0.5ºC, less than 10% hydrolysis had occurred after 120 hours (5 days), equivalent to a half-life of greater than 1 year under environmental conditions (25°C). No further testing was considered necessary.
- Test performance:
- The test was adequately performed meeting the OECD 111 Guideline requirements.
- Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- Substance was hydrolytically stable and therefore transformation products not considered.
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes
- Anomalies or problems encountered (if yes): None encountered.
No transformation products (major or minor) observed and test sample recoveries within the range of 90 to 110% of nominal.
- Results with reference substance:
- Not applicable
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance was determined to be hydrolytically stable under acidic, neutral and basic conditions as determined in a preliminary test. The half-life is considered to be greater than 1 year under environmental conditions (25°C) and accordingly no further testing was deemed necessary.
Reference
Preliminary test results:
|
Ct (mg/L) |
|||||||
pH |
t0h |
t2.4h |
t24h |
t120h |
||||
|
Measured |
Mean |
Measured |
Mean |
Measured |
Mean |
Measured |
Mean |
|
|
|
|
|
|
|
|
|
4 |
760, 740 |
750 |
770, 820 |
790 |
800, 740 |
770 |
810, 790 |
800 |
|
|
|
|
|
|
|
|
|
7 |
840, 830 |
840 |
840, 770 |
810 |
790, 800 |
790 |
770, 790 |
780 |
|
|
|
|
|
|
|
|
|
9 |
800, 760 |
780 |
780, 740 |
760 |
780, 870 |
830 |
770, 840 |
810 |
|
|
|
|
|
|
|
|
|
where Ctis the concentration of MTBE in solution at time th(in hours)
Values in the summary table are presented to 2 significant figures. The mean values were calculated from unrounded data.
Description of key information
The test substance was determined to be hydrolytically stable under acidic, neutral and basic conditions as determined in a preliminary test conducted in accordance with the OECD guideline (Key study). The half-life is considered to be greater than 1 year under environmental conditions (25°C) and accordingly no further testing was deemed necessary. No key value for chemical safety assessment is appropriate.
A supporting publication also shows that the substance is hydrolytically stable under environmentally relevant conditions.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.