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EC number: 202-049-5
CAS number: 91-20-3
1.30 ± 1.06
61.2 ± 11.09
0.60 ± 0.52
0.70 ± 0.82
0.80 ± 0.63
** Denotes statistical significance at p<0.05 and 0.01 respectively
Lower than control mean
In a preliminary
dose-range finding study, naphthalene was administered intraperitoneally
to 5 groups (2 males and 2 females per group) of CD-1 mice at dose
levels of 250, 500, 1000, 3000, and 5000 mg/kg of body weight. Animals
were observed for pharmacotoxic signs for up to 72 hours after dose
signs were observed at all levels evaluated. All
animals died at the 4 highest levels while animals at 250 mg/kg all
survived treatment. Due
to the severity of the signs and the mortality observed in the study,
250 mg/kg was selected as the dose for the Micronucleus Test as an
estimate of the maximum tolerated dose. In
the Micronucleus Test, three groups of ten animals (5 males and 5
females/group) were given single doses by intraperitoneal injection at
250 mg/kg and sacrificed at 30, 48, and 72 hours. Similar
groups, dosed with the positive control, triethlyenemelamine (TEM), and
negative control, corn oil, were evaluated concurrently. Slides
were prepared from the bone marrow of the femurs and stained with Geimsa. Coded
slides were scored for the number of polychromatic erythrocytes (PCE)
with micronuclei in 1000 PCE per animal. The
ratio of polychromatic to normochromatic erythrocytes per 1000
erythrocytes per animal was determined. The
results for naphthalene were negative in the Micronucleus Test at a dose
level of 250 mg/kg at all of the time intervals evaluated. These
findings are based upon the inability of the test substance to produce a
statistically significant increase in the number of micronuclei in 1000
polychromatic erythrocytes per animal in the treated groups versus the
negative control group.
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