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EC number: 202-049-5
CAS number: 91-20-3
The study was performed similar to the proceedings prescribed for the
limit test on acute dermal toxicity by OECD guideline 402 with the
exemption that the amount of naphthalene applied to the laboratory
animals (16,000 mg/kg bw) was much higher than stipulated by the OECD
guideline (2,000 mg/kg). Results are not documented in the report in
detail (e.g. changes in behaviour), but no mortality occurred during the
13 days observation period after a 24 hour dermal application of 16,000
mg/kg naphthalene. No significant changes in body weight have been
observed within the observation period and all animals were without
pathoanatomical findings. The study has been performed similar to actual
OECD guidelines and therefore, the results are regarded to be reliable.
Thus, naphthalene can be regarded as being practically nontoxic via the
dermal route. Furthermore, due to only one out of ten test animals
showing slight oedema, naphthalene can be regarded as not being
corrosive or irritating.
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