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Toxicological information

Carcinogenicity

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Administrative data

Description of key information

In a dermal carcinogenicity study (BRRC, 1982) conducted to GLP, 25 µl of 25% TMSPGE in acetone was not carcinogenic in male C3H mice when administered three times per week. 

Key value for chemical safety assessment

Additional information

Two dermal carcinogenicity studies are available. These studies are of limited value in addressing the carcinogenicity endpoint, but together provide good negative evidence for dermal carcinogenicity.

Justification for classification or non-classification

The available evidence does not suggest that [3-(2,3 -epoxypropoxy)propyl]trimethoxysilane should be classified for carcinogenicity.