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EC number: 219-784-2
CAS number: 2530-83-8
24 hr LC50 = 58 mg/l (30-100)
48 hr LC50 = 55 mg/l (30-100)
72 hr LC50 = 55 mg/l (30-100)
96 hr LC50 = 55 mg/l (30-100)
Short-term toxicity to fish: 96-hour LC50 55 mg/l
(nominal) (OECD 203). The LC50 is equivalent to 45 mg/l when
expressed in terms of [3-(2,3-epoxypropoxy)propyl]silanetriol.
A 96 hour LC50 value of 55 mg/l
(nominal) has been determined for the effects of the registration
substance on the mortality of the freshwater fish Cyprinus carpio
(Infracor Degussa Group, 1996). In view of the test media preparation
method and exposure regime it is likely that the test organisms were
exposed predominantly to the hydrolysis products of the tested substance.
DOC analysis of filtered stock solution confirmed very high recoveries,
although the concentration of substance was sufficiently high that
silanol hydrolysis products could have begun to oligomerise and
theoretically, precipitate. The concentration-response relationship in
this study was very steep with 0% and 100% mortality observed at
successive concentration levels. No sublethal effects were reported. 90%
mortality was observed by the 24 h time point in the upper concentration
level with 100% mortality by 48 h. It is therefore considered that the
effects are predominantly due to the toxicity of the substance (and its
soluble hydrolysis products) rather than physical effects associated
with undissolved materials. Therefore the effects seen in the test are
attributed to a mixture of the parent substance, the
[3-(2,3-epoxypropoxy)propyl]silanetriol hydrolysis product, and soluble
The results may be expressed in terms of concentration of the hydrolysis
product, [3-(2,3-epoxypropoxy)propyl]silanetriol, by applying a
molecular weight correction: (MW of silanol = 194.26 / MW of parent =
236.34) * 55 mg/l = 45 mg/l.
This study is selected as Key as it is the lowest value among the
Several supporting studies on the short-term toxicity of the substance
to fish are available:
A 96 hour LC50 value of 237 mg/l (nominal concentration) has
been determined for the effects of the test substance on mortality of Oncorhynchus
mykiss (Dow Corning, 1978).
A 96 hour LC50 value of 276 mg/l (nominal concentration) has
been determined for the effects of the test substance on mortality of Lepomis
macrochirus (Dow Corning, 1978).
A 96 hour LC50 value of 349 mg/l (nominal concentration) has
been determined for the effects of the test substance on mortality of Pimephales
promelas (Evonik, 1988).
Ecotoxicity testing for this substance is complicated by the hydrolysis
and condensation reactions of the substance.
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane is susceptible to
hydrolysis of both the trimethoxy and epoxide groups. The silanetriol
formed by hydrolysis of the methoxy groups will undergo condensation
reactions to form siloxane dimers, oligomers and polymers, which may
precipitate and cause physical effects on the test organisms.
One study reported an LC50 value of 4.9 mg/l (Evonik, 1994).
However, this study has been disregarded due to major methodological
deficiencies. A very high stock loading rate was used (10.2 g/l).
Oligomers would have formed and it is therefore unclear as to whether
the effects were physical or toxicological. The study is therefore not
considered for the assessment.
[3-(2,3-Epoxypropoxy)propyl]silanetriol is susceptible to further
hydrolysis reactions and the ultimate hydrolysis product
3-[3-(trihydroxysilyl)propoxy]propane-1,2-diol is considered unlikely to
exhibit significant ecotoxic effects based on QSAR estimated E(L)C50s
>>100 mg/l (ECOSAR).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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