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EC number: 219-784-2
CAS number: 2530-83-8
Due to the rapid hydrolysis of the substance, the chemical safely
assessment is based on the intermediate silanol hydrolysis product
In accordance with Column 2 of REACH Annex X, there is no need to
further investigate the effects of this substance in a long-term aquatic
toxicity to fish study because, as indicated in guidance R.184.108.40.206
(ECHA, 2017), the quantitative chemical safety assessment (conducted
according to Annex I of REACH) indicates that the Risk Characterisation
Ratio is well below 1, and therefore the risk is already adequately
controlled and further testing is not justifiable.
The substance is highly water-soluble and has low bioavailability (based
on log Kow <3 (-2.6)).
Based on the short-term aquatic data set the most sensitive trophic
level is fish. Despite long-term Daphnia reproduction test data
being available, as well as an algal NOEC, risk characterisation is
based on the short-term toxicity to fish data, from which a PNEC has
been derived for the purpose of chemical safety assessment. An
assessment factor of 100 was applied to derive the freshwater PNEC using
the short-term fish result. The fact that the PNEC is based on the most
sensitive species means it is unlikely that the aquatic PNEC would be
Overall it is concluded that the risk characterisation conclusion is
sufficiently conservative in respect of any uncertainties and therefore
further in vivo testing is not considered necessary or justified
on ethical grounds.
Details on how the PNEC and the risk characterisation ratios have been
derived can be found in IUCLID Section 6.0 and Chapters 9 and 10 of the
Chemical Safety Report, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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