Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The most reliable study (reliability score 1) was selected as the key study. The human study also has a reliability score of 1. There is also a Guinea-pig Maximisation study (reliability score 2) that supports a negative result. In contrast, other studies suggest the occurrence of positive findings but methodological shortcomings or other deficiencies in reporting are present, so limiting confidence in their reliability.


Migrated from Short description of key information:
In the key experimental animal skin sensitisation study (Evonik Degussa, 1993), a Buehler test conducted with guinea-pigs, [3 -(2,3 -epoxypropoxy)propyl]trimethoxysilane was not sensitising. In addition there is a good quality study that was conducted using human subjects, which also gave negative results.

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
No data available.

Justification for classification or non-classification

The available data do not suggest that [3 -(2,3 -epoxypropoxy)propyl]trimethoxysilane should be classified as a skin or respiratory sensitiser.