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EC number: 208-901-2
CAS number: 546-46-3
-Survival of dams: death at control; 2.72; 12.6; 58.7 and
272 mg/kg: 1, 0, 0, 0 and 1
-Body weight of dams: no compound-related changes compared
-Death:dead fetuses at control; 2.72; 12.6; 58.7 and 272
mg/kg: 0, 0, 7, 1 and 0
- Average fetus weight: no change in treated
groups compared to controls
-Skeletal findings and Soft tissue abnormalities:
Pos. controls (no. of fetuses affected/no. of litters affected):
sternebrae (incomplete oss.) in 96/18, sternebrae (missing) in 33/10,
ribs more than 13in 65/16, extremities (incomplete oss.) in 2/2
-Skeletal findings:(no. of fetuses affected/no. of litters
affected) in control, pos. control, 2.72; 12.6; 58.7 and 272 mg/kg
sternebrae (incomplete oss.): 95/21, 93/21, 66/18, 104/22 and 72/19
sternebrae (missing): 30/12, 27/15, 15/7, 21/8 and 15/9
ribs more than 13: 41/15, 59/18, 57/21, 61/17 and 43/19
extremities (incomplete oss.): 5/4, 6/4, 1/1, 1/1 and 2/2
-Soft tissue abnormalities: no compound related changes
58.7 mg/kg: 1 pup with meningoencephalocele
All other findings were completely in the range of spontaneous
abnormalities found in negative controls.
ORGANS EXAMINED AT NECROPSY (MACROSCOPIC AND MICROSCOPIC):
- Organ weights P and F1: no
- Histopathology P and F1:
P: urogenital tract, number of implantation and resorption sites
F1: All fetuses were examined grossly, one-third of fetuses of
each litter underwent detailed visceral examinations employing 10x
magnification, two-third were examined for skeletal defects
Female hamsters (24-29 animals/group; outbred strain of
golden hamster) received daily doses of 2.72, 12.6, 58.7 and 272
mg/kg bw citric acid by gavage during days 6-10 of gestation. A
control group was included. All animals were observed daily for
appearance and behaviour with particular attention to food
consumption and body weight. Body weights were recorded on day 0,
8, 10 and 14 of gestation. The females were sacrificed at day 14.
The urogenital tract of each animal was examined in detail.
Between 19 and 23 females were pregnant at term in all groups.
No clearly discernible effects on maternal survival, body
weight gains, number of corpora lutea, implantations and
resorptions were observed. The number of live litters, live and
dead foetuses, the foetus weights and sex ratio were not affected
by treatment. No difference in number or kind of abnormalities (in
either soft or skeletal tissues) was found between exposed and
Under the conditions of the test, administration of up to
272 mg/kg bw of citric acid had no adverse effects on adult
hamsters and their foetuses.
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