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EC number: 208-901-2
CAS number: 546-46-3
The data from zinc and citric acid will be used to derived data for trizinc dicitrate Zinc(45-53 wk drinking water study) no treatment related tumours mice (Walters and Roe, 1965, cited in the Zinc metal RAR, 2008).Citric acidNo studies available, however long history of human exposure provides evidence for non-carcinogenicity of citric acid.
of trizinc dicitrate is not expected to differ significantly from the
effects of exposure to the zinc ions and citric acid separately once
absorbed. Therefore, the assessment of this substance will be
based on both citric acid and zinc respectively.
A limited carcinogenicity study where
zinc sulphate was administered to mice in drinking water for 45 – 53
weeks, provided no indication of treatment related tumours (Walters
and Roe, 1965, cited in the Zinc metal RAR, 2008).
are no specific carcinogenicity studies with citric acid, however a long
history of human exposure together with the absence of any treatment
related effects in repeated dose studies mean that it is unlikely that citric
acid would be carcinogenic.
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