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EC number: 208-901-2
CAS number: 546-46-3
exposure of trizinc dicitrate is not expected to differ significantly
from the exposure to citric acid and zinc ions separately in an aqueous
matrix (oral and inhalation) once absorbed. Dermal absorption of trizinc
dicitrate is expected to be negligible due to its physicochemical
properties, namely the low Log KOW (<1). Therefore the toxicokinetics of
trizinc dicitrate should be based on citric acid and zinc separately.
acid has well established and documented metabolic pathways in humans.
It plays a central role in cellular metabolism and has been used as a
food additive, in cosmetics over a long period, as well as being present
in natural food, so the standard approach to toxicokinetics is not
relevant. Similarly, zinc is an essential element, for which organisms
have regulatory mechanisms for uptake and excretion. The metabolism of
zinc has been reviewed in a PFA report (2010), while the toxicokinetics
for zinc are described in detail under the zinc metal RAR (2008).
humans zinc from zinc citrate is absorbed similar to zinc from zinc
gluconate and better then zinc from zinc oxide.
rats comparable level were achieved in the liver and kidney when
comparing zinc sulfate, zinc citrate and zinc gluconate at levels from
3, 15 and 50 mgZN/kg bw/ d over 30 days, while some differences were
observed for zinc levels in dorso-lateral rat prostate.
section contains substantially new data.
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