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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
1996
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The result was obtained from a collection of reliable data which has been subject to peer-review and in which the original sources are traceable. This is a read across from Zinc distearate.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Final report of the safety assessment of lithium stearate, aluminium distearate, aluminium stearate, aluminium tristearate, ammonium stearate, calcium stearate, magnesium stearate, potassium stearate, sodium stearate, and zinc distearate.
Author:
Cosmetic Ingredient Review
Year:
1982
Bibliographic source:
J. Am. Coll. Toxicol. 1, 143-177. [as reported in the zinc distearate RAR 2008]
Reference Type:
secondary source
Title:
Zinc distearate RAR (2008). Risk Assessment Report zinc distearate (CAS 557-05-1) . Final Report, May 2008. European union risk assessment report for zinc distearate, volume 44.
Author:
ZINC RAR
Year:
2008
Report Date:
2008

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material : zinc distearate
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rat
Strain:
other: Albino
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
1 h
Concentrations:
200 mg/l
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 200 mg/L air
Based on:
test mat.
Exp. duration:
1 h
Mortality:
1/10 rats died during 2-wk. observation period. Material was considered non toxic by investigators.
Clinical signs:
No information
Body weight:
No information
Gross pathology:
No information

Any other information on results incl. tables

1/10 rats died within the 14 day observation period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance Zinc distearate is not toxic by inhalation route
Executive summary:

The LC50 value of zinc distearate to rat is >200 mg/L air. The report was lacking in detail. The result is a read accross from zinc distearate (CAS 557-05-1).