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EC number: 208-901-2
CAS number: 546-46-3
Predicted log BCF of 0.5 = 3.2 L/kg wet weight
The bioaccumulation in aquatic species study required in REACH guidance,
Annex IX (Section 9.3.2) does not need to be conducted as the substance
and its hydrolysis products have low potential for bioaccumulation with
a partition coefficient of less than zero (log Kow < 0).
However, an estimated BCF of 3.2 (log BCF = 0.5) was obtained for citric
acid using BCFBAF program which forms part of the Syracuse EPIWEB suite.
The estimated value of citric acid is well below the cut off value of BCF
≥ 500 that is considered to indicate potential for bioaccumulation; the
result indicates that citric acid is not expected to bioaccumulate.
Citrate is found in all eukaryotic cells as an intermediate of the
TCA cycle, which is part of the basic metabolic pathway that generates
useable energy from carbohydrates, proteins and fats. Citric acid is
formed and broken down in the course of this cycle at very high
rates.The weight of evidence of the low estimated BCF, biodegradability
and role in cell metabolism indicate that citric acid is extremely
unlikely to bioaccumulate and testing is not considered necessary for
The accumulation of zinc which is an essential element is
regulated in animals of several fish, crustaceans and mammals. In
mammals, one of the two target species for seconsdary poisoning, both
the absorption of zinc from diet and zinc excretion are regulated. The
process allows mammals with certain limits to maintain the level of zinc
in their body (whole body homeostasis) and to maintain physiologically
required levels of zinc in their tissues both at low and high zinc
dietary intake. In a field study, relatively small difference was found
in the zinc levels of small mammals from control and polluted site. This
observation was due to the homeostatic mechanism. Therefore, the
bioaccumulation potential of zinc is expected to be low.
The effect of trizinc dicitrate when in solution is not expected to
differ significantly from the effects of the citrate anion(H7C6O7-)and
the metal ion separately, so exposure will be to citric acid and the
metal ions separately.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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