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EC number: 208-901-2
CAS number: 546-46-3
10-wk single-blind study was conducted to determine the response
of iron, copper and zinc statusto supplementation
withoral zinc oracombination of zinc and ironsupplementation.
18 female volunteers were
randomly assigned to the two treatment groups and consuming
either50 mg Zn/d as zinc gluconate (Group Z) or 50 mg Fe as
ferrous sulfate monohydrate inaddition to the zn (Group
F+Z).Blood and saliva samples were analysed for Fe, Cu and zn
levels before treatment (pre-treatment) and after 6 and 10 wk of
Z, serum ferritin, hematocrit, and erythrocyte Cu and
zn-superoxidedismutase (ESOD) were significantly lower (p < 0.05)
wk supplementation comparedwith pre-treatment levels. Serum zn
increased (p < 0.01) but no change occurred inserum
ceruloplasmin, hemoglobin, or salivary sediment zn levels. For
Group F-Z,ESODand salivary sediment zn (p < 0.05)
decreased with treatment. Serum ferritin andserum zn increased
significantly, but hemoglobin, hematocrit, and ceruloplasmin
were notaffected by the combination treatment.
Under the conditions of the test,
zinc supplementation significantly lowered iron and copper
status, as assessed through serum ferritin, hematocrit and ESOD
levels and inclusion of Iron with Zinc ameliorates the effect on
Iron but not on Copper status.The NOAEL in this study is less
than 0.83 mg Zn2+/kg bw.
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