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EC number: 208-901-2
CAS number: 546-46-3
accordance with Column 2 of REACH Annex VIII, the activated sludge
respiration inhibition study (required in Section 9.1.4) does not need
to be conducted as the substance is readily biodegradable and the
applied test concentrations are in the range that can be expected in the
influent to a sewage treatment plant.
dicitrate will dissociate in solution to the metal ion and citrate anion
(H7C6O7 -), so exposure of microorganisms will be to the citrate and the
metal ions separately. The effect of trizinc dicitrate is not expected
to significantly differ from the effects of metal ion and citrate
separately. While the toxicity of citric acid is considered to be
negligible (toxicity threshold value of >10000 mg/l), zinc toxicity
(EC50) has been found to be 5.2 mg/l (cited from zinc metal RAR 2008).
Therefore, the toxicity of trizinc dicitrate will be driven by the
toxicity of zinc.
possible to extrapolate the data from zinc to trizinc dicitrate by
converting the zinc results taking into consideration the molecular
weight of both substances*. The EC50 value of 5.2 mg Zn/l is equivalent
to an EC50 value of 15.08 mg/l trizinc dicitrate. This value was
obtained by multiplying with a conversion value of 2.9*.
Molecular weight of trizinc dicitrate/(molecular weight of zinc)*3 =
547/(65*3) = 2.9
The EC50 for zinc metal was obatained from set of data on toxicity tests
with bacterial and protozoans.The available toxicity data were subjected
to pair review and the most reliable data from the peer reviwed
published study (Zinc metal RAR 2008) has been selected as key study.
The bacterial studies gave an EC50 value ranging from 0.74 mg/l to 900
mg/l. In another study conducted using bacterium Pseudomonas putida, an
EC10 values of 1.8 and 0.3 mg/l was obtained (Zinc RAR 2008). The
toxicity test results (LC50) of zinc on protozoans ranges from 0.25 mg/l
to 50 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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