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EC number: 202-216-2
CAS number: 93-08-3
Gene mutation toxicity was performed
to determine the mutagenic nature of the test chemical in vivo.
Micronucleus assay was performed using bone marrow smears of male and
female NMRI mice. The test chemical was dissolved in olive oil and used
at dose levels of 0, 340, 681 or 876 mg/Kg. The chemical was given
intraperitoneally during the 24 hrs study period. The mice were killed
and bone-marrow smears were prepared 30 hr after treatment. The smears
were stained according to the method of Schmid (1976) and were observed
for genetic effects in polychromated erthrocytes. As seen by the
results, the test chemical did not produce genetic effects in the
micronucleus assay performed in NMR1 mice. Hence, it is not likely to
classify as a gene mutant in vivo.
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