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EC number: 202-216-2
CAS number: 93-08-3
in vivo micronucleus test was performed to investigate the mutagenic
potential of 1-(2-naphthyl)ethenoneusing
10-14-week-old NMRI mice. The test chemical was dissolved in olive oil
administered at the doses of 0, 340, 681 and 879 mg/kg by
intraperitoneal injection. The mice were sacrificed, and bone-marrow
smears were prepared 30 hours after treatment. The smears were stained
and the mean numbers of micronucleated polychromatic erythrocytes (PE)
per 1000 polychromatic erythrocytes were calculated.As seen
by the results,the
single intraperitoneal administration of 2'-acetonaphthone did not
increase the frequency of micronucleated
immature erythrocytes in the treated animals. Hence, the administration
of 2-acetonaphthone to NMRI mice did not induced cytogenetic damages
such as structural and numerical chromosome aberrations in the bone
marrow cells and, consequently 2-acetonaphthone was regarded Non-mutagenic(negative)
in mammalian erythrocyte micronucleus test.
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