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EC number: 202-216-2
CAS number: 93-08-3
Classification of 2’-acetonaphthone
for effects in the environment:
The chemical 2’-acetonaphthone (CAS
no. 93-08-3) is used as a flavouring agent or adjuvant. It is also used
as an inert ingredient in non-food pesticide products. The aim was to
assess whether the PBT criterion within Annex XIII was fulfilled for
2’-acetonaphthone.The PBT criterion was herein assessed based on
experimental data in conjunction with standardized environmental fate
models. Here follows a description of the PBT assessment.
The tested substance does not
fulfil the P criterion within Annex XIII based on the assessment that
35-days Closed Bottle test following
the OECD guideline 301 D was performed to determine the ready
biodegradability of the test chemical. The test system included control,
test item and reference item. The concentration of test and reference
item ( Sodium Benzoate) chosen for both the study was 4 mg/L, while that
of inoculum was 32 ml/l. ThOD (Theoretical oxygen demand) of test and
reference item was determined by calculation. % degradation was
calculated using the values of BOD and ThOD for test item and reference
item. The BOD35 value of test chemical was observed to be 0.87 mgO2/mg.
ThOD was calculated as 2.63 mgO2/mg. Accordingly, the % degradation of
the test item after 35 days of incubation at 20 ± 1°C according to
Closed Bottle test was determined to be 33.07 %. Based on the results,
the test chemical, under the test conditions was considered to be
primary inherently biodegradable at 20 ± 1°C over a period of 35 days.
Thus, based on the available
information, it indicates that chemical 2’-acetonaphthone can be
considered to be primary inherently biodegradable in water and thus
likely to be not persistent (not P) in nature.
According to the fugacity model levels
III, the most likely environmental fate for this test chemical is soil (i.e.estimated
to 74%). In soil,2’-acetonaphthonewas expected to have slow mobility
based upon a Log KOC value of 2.834. The half-life in soil (30 days
estimated by EPI suite) indicates that the chemical is not persistent in
soil and the exposure risk to soil dwelling animals is moderate to low.
If released in to the environment,
19.2% of the chemical will partition into water according to the Mackay
fugacity model level III in EPI suite version 4.1 (2017). However, the
half-life (15 days estimated by EPI suite) indicates that the chemical
is not persistent in water and the exposure risk to aquatic animals is
moderate to low.
Moreover, its persistent
characteristic is only observed in the sediment compartment but Fugacity
modelling shows that sediment is not an important environmental fate
(less than 1% i.e. reported as 0.675% when estimated by EPI Suite
Hence it has been concluded that
2’-acetonaphthone is not persistent in nature.
The tested substance does not
fulfil the B criterion within Annex XIII based on the assessment that
The octanol water partition
coefficient of the test chemical was determined to be 2.677,
respectively, which is less than the threshold of 4.5. If this chemical
is released into the aquatic environment, there should be a low risk for
the chemical to bioaccumulate in fish and food chains.
The tested substance does not fulfil
the T criterion within Annex XIII based on the assessment that here
The tested chemical is regarded to be
not classified for carcinogenicity, mutagenicity and reprotoxicity,
Further, there is no evidence of chronic toxicity, as identified by the
classifications STOT (repeated exposure), category 1(oral, dermal,
inhalation of gases/vapours, inhalation of dust/mist/fume) or category 2
(oral, dermal, inhalation of gases/vapours, inhalation of
All of the available short-term
eco-toxicity data for fish, aq. invertebrates and algae for the
substance2’-acetonaphthoneindicates the LC50/EC50 value to be in the
range 5 mg/l to 48.1 mg/L, respectively. These value suggest that the
substance is likely to be hazardous to aquatic organisms at
environmentally relevant concentrations and can be considered to be
classified in ‘Aquatic chronic category 2’ as per the CLP regulation.
On the basis ofthe estimated data
oflong term eco-toxicity data for fish and aq. Invertebrates, the NOEC
value was estimated to be ranges from 1.798 to 2.587 mg/l, respectively.
By speculation, long-term NOEC for aquatic organisms were not expected
for the substance at concentration below 0.01 mg/L based on the data
The chemical was therefore not
considered as hazardous to aquatic environments as per the criteria set
out in Annex XIII.
Based on critical, independent and
collective evaluation of information summarized herein, the tested
compound does not fulfil the P, B and T criterion and has therefore not
been classified as a PBT compound within Annex XIII.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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