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EC number: 202-216-2
CAS number: 93-08-3
A 90-day repeated dose toxicity study
was performed to investigate the toxic nature of 1-(2-naphthyl)ethanone
in 15 male and 15 female rats of the FDRL strain.The test chemical was
diluted in cotton seed oil in a concentration sufficient to provide the
predetermined dosage in 2% of the diet. The daily consumption of the
test chemical was 33 mg/kg body weight/day for males and 36.9 mg/kg body
weight/day for females. The individual body weight and food consumption
was recorded during the administrating period. In addition,
haematological and blood chemical determinations were made on 8 rats of
each sex at a 6-week period, and in all rats at 12 weeks. The tests were
terminated at 90 days and at autopsy, liver and kidney weights were
recorded. The following organs from half the animals in each group were
taken for histological examination: liver, kidneys, stomach, small and
large intestines, spleen, pancreas, heart, lungs, bone marrow, muscle,
brain, spinal cord, bladder, adrenals, thyroid, pituitary, gonads,
salivary glands, and lymph nodes.Measurements of growth, haematological
andbloodclinical chemicalanalysis,gross and histological examinationof
the major organsrevealed no significant adverse effectsrelated to the
test chemical administration.Hence,the repeated exposure to
1-(2-naphthyl)ethenone up to concentration of 33 and 36.9 mg/kg body
weight/day exerted no specific target organ toxicity when administered
in feed to rats for 90 days.The NOAEL (NoObservedAdverseEffectLevel ) of
the test chemical was considered to be 33 mg/kgbody weigh/dayper day for
males and 36.9 mg/kgbody weight/dayfor females.
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