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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication

Data source

Reference
Reference Type:
publication
Title:
skin irritation study
Author:
D. L. J. Opdyke
Year:
1975
Bibliographic source:
Food and Cosmetics Toxicology,1975

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To determine skin irritation potential of test chemical in human using patch test
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): 2'-acetonaphthone
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
human
Strain:
not specified
Details on test animals and environmental conditions:
no data

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
no data
Duration of treatment / exposure:
24 hr
Observation period:
no data
Number of animals:
24 human subjects
Details on study design:
no data

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
no data
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
During 24hr produced one irritation reaction in 24 human subjects
Other effects:
no data

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
Patch test was done in 24 human subjects.Test chemical at full strength for 24 hr produced one irritation reaction in 24 human subjects.Since the test chemical was irritant, it was considered as irritating to human skin.


Executive summary:

In a patch test,24 human subject were used. Test chemical at full strength for 24 hr produced one irritation reaction in 24 human subjects.Since the test chemical was irritant, it was considered as irritating to human skin.