Registration Dossier

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data from various test chemicals
Justification for type of information:
experimental data from various test chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: Refer below principle
Principles of method if other than guideline:
WoE report is prepared based on toxicity to microorganisms study:
1 and 2
GLP compliance:
no
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Tetrahymena pyriformis
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
60 h
Remarks on exposure duration:
48.0 h Study was conducted for 3
Reference substance (positive control):
no
Key result
Duration:
60 h
Dose descriptor:
other: IGC50
Effect conc.:
60.61 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Key result
Duration:
48 h
Dose descriptor:
other: IGC50
Effect conc.:
17 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other:
Remarks:
details not available
Validity criteria fulfilled:
not specified
Conclusions:
1: The inhibitory growth concentration (IGC50) value of test chemical in microorganism (Tetrahymena pyriformis) in a 48 hrs study on the basis of growth inhibition effect obtained was 60.61 mg/L.
2: The inhibitory growth concentration (IGC50) value of test chemical in microorganism (Tetrahymena pyriformis) in a 48 hrs study on the basis of growth inhibition effect obtained was 17 mg/L.
 
Executive summary:

In different studies, the given test chemical, has been investigated for toxicity to microorganisms to a greater or lesser extent. The studies are summarized as below –

In this study both the test chemicals were studied to understand its effects on microorganisms, both the tests were performed in the static regime and the inhibitory growth concentration (IGC50) value was determined. In the first WoE experiment tenure was for 60 hours and the second WoE study was for 48 hours.

It was determined that the IGC for WoE 1and WoE2 is 60.61 and 17 mg/L respectively

Thus from the above effects chemical toxicity value ranges from 17 -60.61 mg/L

Description of key information

WoE1: The inhibitory growth concentration (IGC50) value of test chemical in microorganism (Tetrahymena pyriformis) in a 48 hrs study on the basis of growth inhibition effect obtained was 60.61 mg/L.

WoE 2: The inhibitory growth concentration (IGC50) value of test chemical in microorganism (Tetrahymena pyriformis) in a 48 hrs study on the basis of growth inhibition effect obtained was 17 mg/L.

Key value for chemical safety assessment

EC50 for microorganisms:
60.61 mg/L

Additional information

In different studies, the given test chemical, has been investigated for toxicity to microorganisms to a greater or lesser extent. The studies are summarized as below –

In this study both the test chemicals were studied to understand its effects on microorganisms, both the tests were performed in the static regime and the inhibitory growth concentration (IGC50) value was determined. In the first WoE experiment tenure was for 60 hours and the second WoE study was for 48 hours.

It was determined that the IGC for WoE 1and WoE2 is 60.61 and 17 mg/L respectively

Thus from the above effects chemical toxicity value ranges from 17 -60.61 mg/L